Head & Neck Case Review 2021-01

Head & Neck Case Review

January, 2021

History

An 80-year-old female with a history of squamous cell carcinoma of the tongue that was treated by hemiglossectomy presented a year later with a tender right neck mass. A right radical neck dissection was performed, consisting predominantly of matted cervical lymph nodes with necrosis. In addition, Level IB contained a 3.0 cm well circumscribed, firm, tan-pink mass, shown below.

Images

Quiz

Q1. The histologic features are consistent with:

  • A. Sjogren syndrome
  • B. Atypical lymphoproliferative disorder
  • C. Chronic sclerosing sialadenitis
  • D. Chronic sialadenitis
  • E. Castleman disease

Q2. Which statement is TRUE about this disease?

  • A. It is considered an IgG4-related disease.
  • B. Fine needle aspiration of salivary gland can be diagnostic.
  • C. It can result from compression by an adjacent tumor.
  • D. Obliterative phlebitis is a characteristic feature.
  • E. Lymphoepithelial lesions are characteristic features.

Diagnosis

Contributors

  1. F. Zahra Aly, M.D., Ph.D., Clinical Associate Professor, Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine
  2. Saja Alramadhan, BDS, PGY-3 Resident, Department of Oral and Maxillofacial Pathology, University of Florida College of Dentistry
  3. Nada Al Qaysi, MD, PGY-4 Resident, Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine

Head & Neck Case Review 2020-12

Head & Neck Case Review

December, 2020

History

A boy presented to the pediatric otolaryngology clinic with a chief concern of mass in his left neck of several months’ duration.  He was also experiencing mild intermittent pain. There was no lymphadenopathy. Pre-operative imaging studies identified an intraparotid nodule.  A superficial parotidectomy was performed. H&E sections of the nodule are shown.

Images

Quiz

Q1. Which gene is most likely to harbor an alteration in this patient’s tumor?

  • A. MAML2
  • B. NR4A3
  • C. PLAG1
  • D. PTEN

Q2. This tumor type is associated with a considerable rate of recurrence.

  • A. True
  • B. False

Diagnosis

Contributor

Jiancong Liang, MD PhD
Assistant Professor
Department of Pathology, Microbiology and Immunology
Vanderbilt University Medical Center, Nashville, TN