Head & Neck Case Review
A 73-year-old man presented with right nasal obstruction and epiphora for about a year. On nasal endoscopy a smooth submucosal mass attached to the anterior part of the inferior turbinate and extending to the septum was identified. CT imaging also confirmed the presence of an ill-defined soft tissue mass confined to the nasal cavity. The patient subsequently underwent resection. H&E slides and immunostains are shown. The following stains were negative: cytokeratin AE1/AE3, CD34, S-100, SOX10, and myogenin.
Q1. The following genetic syndromes have been associated with this disease in children except:
- A. Li-Fraumeni syndrome
- B. Costello syndrome
- C. Neurofibromatosis type 1
- D. Beckwith-Wiedemann syndrome
- E. Cowden syndrome
Q2. The most common site of disease outside the Head and Neck is the paratesticular region.
- A. True
- B. False
Mitra Mehrad, M.D.
Department of Pathology, Microbiology and Immunology
Vanderbilt University Medical Center, Nashville, TN