Head & Neck Case Review 2021-02

Head & Neck Case Review

February, 2021


A 65 year-old male with no significant past medical history presents with fatigue, difficulty swallowing, and voice changes for several months duration. CT scan showed an 8 cm left-sided neck mass. The patient underwent left hemithyroidectomy and parathyroidectomy. CT imaging, H&E sections, and immunostains of the mass are shown.



Q1. All of the following are characteristic features of this tumor, EXCEPT:

  • A. Invasive growth involving adjacent structures
  • B. Vascular and/or perineural invasion
  • C. Nodular growth pattern with broad bands of fibrous connective tissue
  • D. Rare recurrence after resection

Q2. CDC73 mutation is the molecular driver in the pathogenesis of this tumor.

  • A. True
  • B. False



Mitra Mehrad, MD
Assistant Professor
Department of Pathology, Microbiology and Immunology
Vanderbilt University Medical Center, Nashville, TN