Head & Neck Case Review
A 44-year-old woman presented with a 2-month history of right mandibular pain and mild swelling. Recent developments included paresthesia along the lip and right side of the chin. A cone beam CT study showed irregular resorption of bone including erosion of the buccal cortex. Representative axial and coronal slices of the mass along with the H&E stained sections and immunostains of the biopsied tissue are shown.
Q1. What is the characteristic genetic event in this tumor in children?
- A. PAX 3/7-FOX01 gene fusion
- B. FGFR4, RAS, AKT pathway mutations
- C. PTEN hypermethylation
- D. NCOR2 or VGLL2 gene fusion
Q2. Which one of the following is a morphologic variant of this tumor?
- A. Sclerosing
- B. Embryonal
- C. Pleomorphic
- D. Alveolar
Yeshwant B. Rawal, BDS, MDS, MS
Professor, Department of Surgical Sciences
Marquette University School of Dentistry, Milwaukee, WI