Head & Neck Case Review 2022-09

Head & Neck Case Review

September, 2022


A 72-year-old female presents with hoarseness of voice and dysphagia. A 3.2 x 1.9 x 2.7 cm heterogenous nodule in the left neck adjacent to the submandibular gland is noted on ultrasound. An ultrasound guided core needle biopsy is performed.


Link to Virtual Slide HERE!


1. Which of the following is TRUE?

  • A. These tumors are defined by PAX8::GLIS3 gene rearrangements.
  • B. These tumors are typically driven by mutations in the succinate dehydrogenase complex.
  • C. Sclerosis is a key feature to predict aggressive (i.e. metastatic) potential.
  • D. They often show low and high molecular weight cytokeratin expression.

2. TRUE or FALSE: 10% of these tumors are familial/inherited.



Grayson Cole, DDS
PGY-3 Oral Pathology Resident
University of Pittsburgh School of Dental Medicine
University of Pittsburgh Medical Center

Raja R. Seethala, MD
Professor of Pathology and Otolaryngology
University of Pittsburgh Medical Center