Head & Neck Case Review
A 19-year-old female presented with a rapidly enlarging 7.5 cm left-sided thyroid mass. Multiple, bilateral pulmonary nodules measuring up to 2 cm were present on CT scan, consistent with metastatic disease. She underwent total thyroidectomy and left neck dissection followed by radioactive iodine ablation. Images from the thyroid resection are shown below.
Q1. Which gene is most likely to harbor a mutation in this patient’s tumor?
- A. BRAF
- B. DICER1
- C. RAS
- D. TERT
Q2. The prognosis for this tumor type is better in young people than in older adults.
- A. True
- B. False
Rebecca Chernock, M.D.
Department of Pathology and Immunology
Washington University in St. Louis