Head & Neck Case Review 2024-03

Head & Neck Case Review

March, 2024


A 12-year-old female presented with jaw pain and a firm mass involving the mandible. Imaging revealed an expansile lesion centered around the mandibular ramus with uniform and sclerotic density, root resorption, and prominence of involved periodontal ligament spaces. The patient underwent a hemi-mandibulectomy, which revealed a poorly demarcated tan mass surrounding and causing root resorption of the molar teeth. Histologic examination was performed.



1. Which of the following is a common molecular finding associated with this neoplasm?

  • A. SATB2 rearrangement
  • B. MDM2 amplification
  • C. GNAS mutation
  • D. USP6 rearrangement

2. True or False: The mandible is the most common site for this neoplasm.


Melad N. Dababneh, MBBS
head and neck pathology fellow, Cleveland Clinic

Ivan J. Stojanov, DMD
staff pathologist, Cleveland Clinic

Head & Neck Case Review 2021-06

Head & Neck Case Review

June, 2021


A 44-year-old woman presented with a 2-month history of right mandibular pain and mild swelling. Recent developments included paresthesia along the lip and right side of the chin. A cone beam CT study showed irregular resorption of bone including erosion of the buccal cortex. Representative axial and coronal slices of the mass along with the H&E stained sections and immunostains of the biopsied tissue are shown.



Q1. What is the characteristic genetic event in this tumor in children?

  • A. PAX 3/7-FOX01 gene fusion
  • B. FGFR4, RAS, AKT pathway mutations
  • C. PTEN hypermethylation
  • D. NCOR2 or VGLL2 gene fusion

Q2. Which one of the following is a morphologic variant of this tumor?

  • A. Sclerosing
  • B. Embryonal
  • C. Pleomorphic
  • D. Alveolar



Yeshwant B. Rawal, BDS, MDS, MS
Professor, Department of Surgical Sciences
Marquette University School of Dentistry, Milwaukee, WI