Head & Neck Case Review 2021-06

Head & Neck Case Review

June, 2021

History

A 44-year-old woman presented with a 2-month history of right mandibular pain and mild swelling. Recent developments included paresthesia along the lip and right side of the chin. A cone beam CT study showed irregular resorption of bone including erosion of the buccal cortex. Representative axial and coronal slices of the mass along with the H&E stained sections and immunostains of the biopsied tissue are shown.

Images

Quiz

Q1. What is the characteristic genetic event in this tumor in children?

  • A. PAX 3/7-FOX01 gene fusion
  • B. FGFR4, RAS, AKT pathway mutations
  • C. PTEN hypermethylation
  • D. NCOR2 or VGLL2 gene fusion

Q2. Which one of the following is a morphologic variant of this tumor?

  • A. Sclerosing
  • B. Embryonal
  • C. Pleomorphic
  • D. Alveolar

Diagnosis

Contributor

Yeshwant B. Rawal, BDS, MDS, MS
Professor, Department of Surgical Sciences
Marquette University School of Dentistry, Milwaukee, WI

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