Head & Neck Case Review 2021-07

Head & Neck Case Review

July, 2021

History

A 50-year-old man presents with a 6-month history of a left tongue lesion which was biopsied. Characteristic H&E stained sections and one immunostain are shown.

Images

Quiz

Q1. Which of the following is true regarding this lesion?

  • A. It is the result of a proliferation of histiocytes.
  • B. The lesional cells are filled with PAS+, diastase resistant granules.
  • C. The overlying mucosal process is characteristic of basal cell carcinoma.
  • D. Leukoplakia and erythroplakia are precursors of this lesion.

Q2. Which immunohistochemical stain is used to help diagnose this lesion and is shown here?

  • A. CK5/6
  • B. SOX10
  • C. S100
  • D. Desmin

Diagnosis

Contributor

Qiuying Shi, MD, MS (Assistant Professor, Lead author)
Oluwaseun Ogunbona, MD, PhD (PGY3 resident)
Department of Pathology
Emory University Hospital Midtown
Emory University School of Medicine, Atlanta, GA