Head & Neck Case Review 2021-07

Head & Neck Case Review

July, 2021


A 50-year-old man presents with a 6-month history of a left tongue lesion which was biopsied. Characteristic H&E stained sections and one immunostain are shown.



Q1. Which of the following is true regarding this lesion?

  • A. It is the result of a proliferation of histiocytes.
  • B. The lesional cells are filled with PAS+, diastase resistant granules.
  • C. The overlying mucosal process is characteristic of basal cell carcinoma.
  • D. Leukoplakia and erythroplakia are precursors of this lesion.

Q2. Which immunohistochemical stain is used to help diagnose this lesion and is shown here?

  • A. CK5/6
  • B. SOX10
  • C. S100
  • D. Desmin



Qiuying Shi, MD, MS (Assistant Professor, Lead author)
Oluwaseun Ogunbona, MD, PhD (PGY3 resident)
Department of Pathology
Emory University Hospital Midtown
Emory University School of Medicine, Atlanta, GA