Head & Neck Case Review
A 30 year old patient presented with a pathologic mandible fracture and loose teeth following minimal trauma. CT imaging revealed a thin mandibular body and ramus with superimposed areas of permeative destruction and erosion, and a minimally displaced fracture of the mandibular angle. The ipsilateral maxillary sinus appeared hypoplastic. A segmental mandibulectomy with reconstruction was performed. The disease progressed within one year requiring total mandibulectomy and prosthetic replacement.
Q1. What is the diagnosis
- A. Paget disease
- B. Gorham-Stout disease
- C. Angiosarcoma
- D. Fibrous dysplasia
Q2. What are the characteristic histologic features?
- A. Malignant lymphatic or vascular proliferation involving bone
- B. Benign lymphatic or vascular proliferation and osteolysis
- C. Cystic spaces lined by fibrous tissue with osteoclast-like giant cells
- D. Osteonecrosis with a reactive lymphatic or vascular proliferation
Manuel Lora Gonzalez, MD
Selective Surgical Pathology (Head and Neck) Fellow, PGY-6
Department of Pathology and Immunology
Washington University in St. Louis