Head & Neck Case Review 2020-02

Head & Neck Case Review

February, 2020

History

A 73-year-old man presented with right nasal obstruction and epiphora for about a year. On nasal endoscopy a smooth submucosal mass attached to the anterior part of the inferior turbinate and extending to the septum was identified. CT imaging also confirmed the presence of an ill-defined soft tissue mass confined to the nasal cavity. The patient subsequently underwent resection. H&E slides and immunostains are shown. The following stains were negative: cytokeratin AE1/AE3, CD34, S-100, SOX10, and myogenin.

Images

Virtual H&E slide

Quiz

Q1. The following genetic syndromes have been associated with this disease in children except:

  • A. Li-Fraumeni syndrome
  • B. Costello syndrome
  • C. Neurofibromatosis type 1
  • D. Beckwith-Wiedemann syndrome
  • E. Cowden syndrome

Q2. The most common site of disease outside the Head and Neck is the paratesticular region.

  • A. True
  • B. False

Diagnosis

Contributor

Mitra Mehrad, M.D.
Assistant Professor
Department of Pathology, Microbiology and Immunology
Vanderbilt University Medical Center, Nashville, TN

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